Department of Methodology and Statistics, Faculty of Health, Medicine and Life Sciences Maastricht University Maastricht The Netherlands Mater Misericordiae University Hospital, Trinity College Dublin Dublin Ireland Nutrition & Dietetics Department Guy’s & St. Center of Inherited Metabolic Diseases, Metabolic Lab PCMA Wilrijk Belgium Department of Metabolic Disorders in Children Antwerp University Hospital UZA Edegem Belgium Department of Bone and Mineral Metabolism Institute of Child Health, Agia Sophia Children’s Hospital Athens Greece
Department of Molecular and Medical Genetics School of Medicine, Oregon Health and Science University Oregon USA Department of Pediatrics Academic Medical Center, Emma Children’s Hospital, University of Amsterdam Amsterdam The Netherlands Department of Pediatrics and Department of Clinical Genetics Maastricht University Medical Center Maastricht The Netherlands
Bosch: conception and design, analysis and interpretation of data, drafting the chapter, revising the chapter critically for important intellectual content.Īll authors read and approved the manuscript before submission. Estela Rubio-Gozalbo: conception and design, analysis and interpretation of data, drafting the chapter, revising the chapter critically for important intellectual content.Īnnet M. Waisbren: acquisition of data, revising the chapter critically for important intellectual content. Rein Vos: statistical design, revising the chapter critically for important intellectual content. Treacy: acquisition of data, revising the chapter critically for important intellectual content. Joanna Gribben: acquisition of data, revising the chapter critically for important intellectual content.Įileen P. van Calcar: analysis and interpretation of data, revising the chapter critically for important intellectual content.Īrtemis Doulgeraki: acquisition of data, revising the chapter critically for important intellectual content.įrançois Eyskens: analysis and interpretation of data, revising the chapter critically for important intellectual content. Lindsey Welling: conception and design, acquisition of data, analysis and interpretation of data, drafting the chapter, revising the chapter critically for important intellectual content. In conclusion, clinicians should ensure appropriate preventive and therapeutic measures for CG patients.īritt van Erven: conception and design, acquisition of data, analysis and interpretation of data, drafting the chapter, revising the chapter critically for important intellectual content. This indicates that bone health is mildly affected in CG and that more patients, compared to the general population, are at risk for a BMD Z-score ≤−2 SD. Results from studies included in the descriptive analysis ( n = 7) show that vitamin D levels were frequently in the low reference range, whereas serum calcium levels were within reference range.Ĭonclusion: The mean BMD Z-score in the CG population is −0.7, which is lower than in the general population, though still within two SD of the reference mean of zero.
BMD Z-scores in children and adults with CG measured at the lumbar spine (LBMD 4 studies n = 112), total hip (HBMD 2 studies n = 58), and femoral neck (FBMD 2 studies n = 73) were assessed. Results: Four studies were included in the meta-analysis. Selection of relevant manuscripts, risk of bias assessment, and data extraction were performed independently by two investigators. Methods: Systematic search strategies were developed by an experienced clinical librarian. The secondary objective was to evaluate other indicators of bone status through a descriptive analysis. Low BMD was defined as a Z-score ≤−2 standard deviations (SD). The primary objective of this systematic review with meta-analysis was to determine the extent of bone mineral density (BMD) Z-score reduction. Introduction: Previous studies have reported an association between classic galactosemia (CG) and decreased bone mass.
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